Lewis Laboratory


These are the recent publications from our group. Click on the link to access the publications - if for some reason the paper isn't freely available to download, contact the lab and we will be happy to send you a PDF. For a full list of publications click here.

Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H and Plun-Favreau H (2013) “The Parkinson‘s disease linked proteins Fbxo7 and Parkin interact to mediate mitophagy” In press, Nature Neuroscience

Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MPM, Plun-Favreau H, Giunti P, Tooze S, Bandopadhyay R and Lewis PA (2013) “Inhibition of LRRK2 kinase activity stimulates macroautophagy” In press, BBA – Molecular Cell Research

Manzoni C and Lewis PA (2013) “Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies” In press, FASEB Journal

Trabzuni D, Ryten M, Emmett W, Ramasamy A, Lackner KJ, Zeller T, Walker R, Smith C, Lewis PA, Mamais A, de Silva R, Vandrovcova J, International Parkinson Disease Genomics Consortium (IPDGC), Hernandez D, Nalls MA, Sharma M, Garnier S, Lesage S, Simon-Sanchez J, Gasser T, Heutink P, Brice A, Singleton A, Cai H, Schadt E, Wood NW, Bandopadhyay R, Weale ME, Hardy J and Plagnol V (2013) “Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus” PLoS ONE 7: e70724

Mamais A, Raja M, Manzoni C, Dihanich S, Lees A, Moore D, Lewis PA and Bandopadhyay R (2013) “Divergent alpha synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology compared to idiopathic cases” Neurobiology of Disease 58: 183–190

Paisan-Ruiz C, Lewis PA and Singleton A (2013) “LRRK2: cause, risk and mechanism” Journal of Parkinson's Disease 3: 85-103

Kara E, Lewis PA, Ling H, Proukakis C, Houlden H and Hardy J (2013) “Alpha synuclein mutations cluster around a putative protein loop” Neuroscience Letters 546: 67-70

Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis PA, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL (2013) “Synucleinopathy associated with G51D SNCA mutation: A link between Parkinson’s disease and multiple system atrophy?” ACTA Neuropathologica 125: 753-769

Lewis PA (2012) “James Parkinson: the man behind the shaking palsy” Journal of Parkinson’s disease 2: 181-187

Jebelli J, Dihanich S, Civiero L, Manzoni C, Greggio E and Lewis PA (2012) “GTP binding and intramolecular regulation by the ROC domain of DAPK1” Scientific Reports 2: 695

Lewis PA and Alessi DR (2012) “Deciphering Leucine Rich Repeat Kinase 2 function and targeting its dysfunction in disease” Biochemical Society Transactions 40: 1039-1041

Wray S, Self M, NINDS Parkinson’s Disease iPSC Consortium, NINDS Huntington’s Disease iPSC Consortium, NINDS ALS iPSC Consortium, Lewis PA, Taanman J, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin U, Houlden H, Morris HR, Healy D, Marti-Masso JF, Preza E, Barker S, Sutherland M, Corriveau RA, D’Andrea M, Schapira AHV, Uitti RJ, Guttman M, Opala G, Jasinska-Myga B, Puschmann A, Nilsson C, Espay AJ, Slawek J, Gutmann L, Boeve BF, Boylan K, Stoessl AJ, Ross OA, Maragakis NJ, Van Gerpen J, Gerstenhaber M, Gwinn K, Dawson TM, Isacson O, Marder KS, Clark LN, Przedborski SE, Finkbeiner S, Rothstein JD, Wszolek ZK, Rossor MN, Hardy J (2012) “Creation of an open-access mutation-defined fibroblast resource for neurological disease research” PLoS ONE 7: e43099

Patani R, Lewis PA, Trabzuni D, Proudfoot C, Wyllie DJA, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S and Ryten M “Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole genome gene expression and splicing analysis” Journal of Neurochemistry 122: 738-751

Lewis PA and Cookson MR (2012) “Gene expression in the Parkinson’s disease brain” Brain Research Bulletins 88: 302-312

Lewis PA (2012) “Assaying the kinase activity of LRRK2” Journal of Visualized Experiments 59: e3495

Lewis PA and Manzoni C (2012) “LRRK2 and human disease: a complicated question or a question of complexes?” Science Signaling 5: pe2

Devine M, Ryten M, Vodicka P, Thomson AJ, Houlden H, Burdon T, Cavaleri F, Drummon NJ, Nagano M, Taanman JW, Schapira A, Gwinn K, Hardy J, Lewis PA and Kunath T (2011) “Parkinson’s disease iPSCs with triplication of the α-synuclein locus” Nature Communications 2: 440

Devine M, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, Schapira A, Wolozin B, Bandopadhyay R, van der Brug M and Lewis PA (2011) “Mutations in LRRK2 do not alter gene expression in cell model systems or human brain tissue” PLoS ONE 6: e22489

Wray S and Lewis PA (2010) “A tangled web – tau and sporadic Parkinson’s disease” Frontiers in Neurodegenerative Disease 1:a150

Plun-Favreau H, Lewis PA, Hardy J, Miguel-Martins L and Wood NW (2010) “Cancer and Neurodegeneration: between the devil and the deep blue sea” PLoS Genetics 12: e1001257

Li Y, Dunn L, Greggio E, Krumm B, Jackson GS, Cookson MR, Lewis PA and Deng J (2009) “The R1441C mutation alters the folding properties of the ROC domain of LRRK2” BBA – Molecular Basis of Disease 12: 1194-97

Hardy J, Lewis PA, Revesz T, Lees A and Paisan-Ruiz C (2009) “The genetics of Parkinson’s syndromes: a critical review” Current Opinion in Genetics and Development 19: 254-65

Lewis PA (2009) “The ROCO proteins in health and disease” Biology of the Cell 101: 183-91

Devine MJ and Lewis PA (2008) “Emerging pathways in Genetic Parkinson’s disease: tangles, Lewy bodies and LRRK2” FEBS Journal 275: 5748-57  
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