Lewis Laboratory

Lab members

Patrick A. Lewis
I have been working on neurodegenerative diseases for over ten years, first at the Mayo Clinic in Florida where I worked on the molecular basis of Alzheimer's disease. I then carried out graduate studies at the Medical Research Council Prion Unit at the UCL Institute of Neurology where I completed a PhD on the molecular characteristics of the Scrapie agent in 2005. I started working on Parkinson's disease at the National Institute on Aging in Bethesda in the Laboratory of Neurogenetics under Mark Cookson. It was in Bethesda that I first came across Leucine Rich Repeat Kinase 2, LRRK2, a protein which I have been investigating ever since. In 2007 I returned to the UCL Institute of Neurology and the Department of Molecular Neuroscience.
Claudia Manzoni

I graduated in Pharmaceutical Biotechnology at the University of Milan and, to obtain my degree, I worked at the Mario Negri Institute for Pharmacological Research for 18 months on a project concerning the description of the synthetic peptide PrP82-146 as an in vitro model for prion amyloid. After graduation I remained at the Mario Negri Institute as research fellow in the lab. of Protein Chemistry and Biochemistry. In January 2006 I started my PhD with the Open University and I graduated in April 2010. For my PhD project I worked with Abeta amyloid investigating Abeta-induced neuronal toxicity and confirming that Abeta peptides, when appropriately folded, can impair neuronal viability following protein-mediated “docking” onto cell membranes. The aim of my study was to identify membrane proteins which might have a role in triggering Abeta-induced toxicity after binding to Abeta oligomers. In March 2010 I joined the Department of Molecular Neuroscience as associate research fellow under the supervision of Dr. Lewis working on a project concerning the characterization of fibroblasts from PD patients with mutations in the LRRK2 protein, with specific interest for the mTOR and the TNFa signalling pathways.

Marie Bordone
I come from Portugal where I graduated at Universidade do Algrave in Biomedical Science in 2012. I then applied for the Biomedical MSc 2012/2014 at the same university and I’m now at the second year of the masters degree. For my masters thesis, I will be working on Parkinson disease under Dr Patrick Lewis at the University of Reading investigating the cellular basis of disease linked to PRKRA and WDR45.

Sybille Dihanich

I studied Biotechnology at the University of Applied Sciences in Vienna and finished my studies in June 2007. As part of my degree I was working on a 10-months ERASMUS studentship at the Institute of Phsychiatry (King's College London). My work at the IoP was carried out in Dr. Jonathan Cooper's lab which is investigating a group of lysosomal storage disorders called Batten Disease. After finishing my degree I stayed on in the Cooper lab as a PhD student investigating cell renewal (neurogenesis) and microglial biology in various models of Batten Disease. In February 2011 I joined the Department of Molecular Neuroscience where I am working under the supervision of Dr. Patrick Lewis. Within my project I am aiming to characterise the functions and properties of MASL1, one of the ROCO proteins which have an involvement in Parkinson Disease and other disorders.

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